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KMID : 1161420160190111065
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Journal of Medicinal Food
2016 Volume.19 No. 11 p.1065 ~ p.1073
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Procoagulant Substance and Mechanism of Myristica fragrans
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Zhang Yong
Xie Pingyao
Guo Xiuchun
Kang Wenyi
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Abstract
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The effect and mechanisms of Myristica fragrans on blood clotting were evaluated by evaluating blood coagulation time and the fibrinolytic system. The compounds 2 and 5 were isolated from the herbal extract and their activities were assessed for the first time. None of the tested compounds had fibrinolytic activity, but could inhibit the fibrinolytic activity of urokinase. Compound 2 showed the highest inhibitory activity (IC50?=?1.747?mg·mL?1) followed by compounds 4 (IC50?=?1.818?mg·mL?1) and 1 (IC50?=?2.407?mg·mL?1), which were higher than that of the compound in Danshen drug tablets (IC50?=?6.577?mg·mL?1) used in China. Moreover, compounds 1 and 2 showed strong α-glucosidase inhibitory activity in a dose-dependent manner with IC50 values 21.76?±?0.59 and 21.31?±?0.00?μg·mL?1, respectively. These results demonstrated that the compounds are promising candidates as procoagulant and antidiabetic agents.
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KEYWORD
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Myristica fragrans, coagulation activity, α-glucosidase inhibitory activity
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